Cryptic crossword clue
Upset by rejection of offer to contain rust problem

The most common and most likely answer to this crossword clue is the 7 letter word DISTURB

I've seen this crossword clue in The Guardian
D
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Buddy explains!

The straight part
We know that "Upset" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case upset = disturb.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISTURB mean?

DISTURB noun
  1. Disturbance
DISTURB verb
  1. To confuse a quiet, constant state or a calm, continuous flow, in particular: thoughts, actions or liquids.
  2. To divert, redirect, or alter by disturbing.
  3. To have a negative emotional impact; to cause emotional distress or confusion.

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