Cryptic crossword clue
Upset fellow about wrong condition of small things 6

The most common and most likely answer to this crossword clue is the 6 letter word NANISM

I've seen this crossword clue in Independent
N
A
N
I
S
M

Buddy explains!

The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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