The most common and most likely answer to this crossword clue is the 8 letter word EMBITTER
I've seen this crossword clue in The Daily Telegraph
E
M
B
I
T
T
E
R
More clues leading to the result EMBITTER
- This writer knocked back pub drink in anger
- Tiring complaint about drink being sour
- Make sour beer after middle of November
- Tribe met in the wars turn hostile
- Picaroon knocked back drink in anger
- Cause to be resentful of one abstainer in throes of dwindling passion
- Upset first person held back by drink
- I’m better after digesting poison
- Setter upset, beer upset!
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EMBITTER mean?
EMBITTER verb- To cause to be bitter.