Cryptic crossword clue
Upset nurse coming in profoundly hammered 6

The most common and most likely answer to this crossword clue is the 6 letter word PEENED

P
E
E
N
E
D

Buddy explains!

The straight part
We know that "hammered" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hammered = peened.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PEENED mean?

PEENED verb
  1. To shape metal by striking it, especially with a peen.

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