Cryptic crossword clue
Upset, or excite, a run down severely 9

The most common and most likely answer to this crossword clue is the 9 letter word EXCORIATE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "run down severely" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case run down severely = excoriate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EXCORIATE mean?

EXCORIATE verb
  1. To wear off the skin of; to chafe or flay.
  2. To strongly denounce or censure.

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