The most common and most likely answer to this crossword clue is the 4 letter word HURT
H
U
R
T
More clues leading to the result HURT
- Damage that’s terminal in watch you repair last
- You are reportedly in hospital with temperature, injured
- A half-day’s cycling injury
- King in humble abode distressed
- Upset, you briefly stopped therapy
- Injure actor
- Arthur tries to conceal injury
- After passage of time, reality turns into pain
- Damage produced by river getting into shack
Buddy explains!

The straight part
We know that "Upset" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case upset = hurt.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HURT mean?
HURT noun- An emotional or psychological humiliation or bad experience.
- A bodily injury causing pain; a wound or bruise.
- Injury; damage; detriment; harm
- A roundel azure (blue circular spot).
- A band on a trip-hammer helve, bearing the trunnions.
- A husk.
- To be painful.
- To cause (a creature) physical pain and/or injury.
- To cause (somebody) emotional pain.
- To undermine, impede, or damage.
- Wounded, physically injured.
- Pained.