Cryptic crossword clue
Upsetting depression’s overwhelming great man – one’s not perfectly rounded 8

The most common and most likely answer to this crossword clue is the 8 letter word SPHEROID

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "one’s not perfectly rounded" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one’s not perfectly rounded = spheroid.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SPHEROID mean?

SPHEROID noun
  1. A solid of revolution generated by rotating an ellipse about its major (prolate), or minor (oblate) axis.
SPHEROID adjective
  1. Of a shape similar to a squashed sphere.

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