Cryptic crossword clue
Urine not flowing? It’s definitely not a big thing! 8

The most common and most likely answer to this crossword clue is the 8 letter word NEUTRINO

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "It’s definitely not a big thing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it’s definitely not a big thing = neutrino.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEUTRINO mean?

NEUTRINO noun
  1. An elementary particle that is classified as a lepton, and has an extremely small but nonzero mass and no electric charge. It interacts with the surroundings only via the weak force or gravitation, making it very difficult to detect.

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