Cryptic crossword clue
US chemist may measure liquid in it, yet holds on 5

The most common and most likely answer to this crossword clue is the 5 letter word BURET

B
U
R
E
T

Buddy explains!

The straight part
We know that "US chemist may measure liquid in it" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case us chemist may measure liquid in it = buret.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BURET mean?

BURET noun
  1. A glass tube with fine gradations and a stopcock at the bottom, used in laboratory procedures for accurate fluid dispensing and titration.
  2. An altar cruet.

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