The most common and most likely answer to this crossword clue is the 6 letter word TUCSON
I've seen this crossword clue in Financial Times
T
U
C
S
O
N
More clues leading to the result TUCSON
- Workers' organisation’s functioning in US city
- Boy joins workers' organisation in US city
- US city numbers decrease – should be going up
- No tailback in city
- Inhabitant supporting workers’ representatives in US city
- Like a tailless rabbit back in US city
- Starts unloading cargo, so not going over and over the city
Buddy explains!

The straight part
We know that "US city" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case us city = tucson.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.