The most common and most likely answer to this crossword clue is the 5 plus 8 letter word JERRY SPRINGER
I've seen this crossword clue in Financial Times
J
E
R
R
Y
S
P
R
I
N
G
E
R
Buddy explains!
The straight part
We know that "US talk show host" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case us talk show host = jerry springer.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.