Cryptic crossword clue
Use fiction in a way that’s easily picked up 10

The most common and most likely answer to this crossword clue is the 10 letter word INFECTIOUS

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Buddy explains!

The straight part
We know that "easily picked up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case easily picked up = infectious.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INFECTIOUS mean?

INFECTIOUS adjective
  1. (of an illness) Transmitted from one person to another, usually through the air breathed.
  2. (of a person) Able to infect others.
  3. (of feelings and behaviour) Spreading quickly from one person to another.
  4. Memorable and invoking excitement or interest.

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