Cryptic crossword clue
Uses machines to replace regular faculty members with no friends 9

The most common and most likely answer to this crossword clue is the 9 letter word AUTOMATES

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The straight part
We know that "Uses machines" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case uses machines = automates.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AUTOMATES mean?

AUTOMATES verb
  1. To replace or enhance human labor with machines.

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