Cryptic crossword clue
Using wire, strangulates targets walking around centre of Vancouver 8

The most common and most likely answer to this crossword clue is the 8 letter word GAROTTES

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Buddy explains!

The straight part
We know that "Using wire, strangulates" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case using wire, strangulates = garottes.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GAROTTES mean?

GAROTTES noun
  1. A cord, wire or similar used for strangulation.
  2. An iron collar formerly used in Spain to execute people by strangulation.

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