The most common and most likely answer to this crossword clue is the 7 letter word AGAINST
I've seen this crossword clue in The Times
A
G
A
I
N
S
T
More clues leading to the result AGAINST
- Hostile to touching
- Opposed to a way to secure advantage
- Hostile to saga not starting on fashionable street
- V — a sign that’s rude in vacuous affront
- Not in favour of one on Benefit Street
- Opposed to introduction of agreed profits before time
- Opposed to a holy man pocketing reward
- Opposing military commander isn’t bad
- Not for touching?
- Opposed to a way profit is secured
Buddy explains!

The straight part
We know that "V" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case v = against.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does AGAINST mean?
AGAINST preposition- In a contrary direction to.
- In physical opposition to; in collision with.
- In physical contact with, so as to abut or be supported by.
- Close to, alongside.
- In front of; before (a background).
- In contrast or comparison with.
- In competition with, versus.
- Contrary to; in conflict with.
- In opposition to.
- Of betting odds, denoting a worse-than-even chance.
- In exchange for.
- As counterbalance to.
- As a charge on.
- As protection from.
- In anticipation of; in preparation for (a particular time, event etc.).
- (Hollywood) To be paid now in contrast to the following amount to be paid later under specified circumstances, usually that a movie is made or has started filming.
- Exposed to.
- By the time that (something happened); before.