Cryptic crossword clue
Vacating house before nuclear meltdown is very hard 9

The most common and most likely answer to this crossword clue is the 9 letter word HERCULEAN

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "very hard" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case very hard = herculean.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HERCULEAN mean?

HERCULEAN adjective
  1. Of extraordinary might, power, size, etc.; suggesting Hercules in size or strength.
  2. Requiring a huge amount of work; of extraordinary difficulty.

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