Cryptic crossword clue
Vain Englishman and American crossing river 7

The most common and most likely answer to this crossword clue is the 7 letter word POMPOUS

I've seen this crossword clue in The Times
P
O
M
P
O
U
S

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The straight part
We know that "Vain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case vain = pompous.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POMPOUS mean?

POMPOUS adjective
  1. Affectedly grand, solemn or self-important.

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