The most common and most likely answer to this crossword clue is the 4 letter word SCAB
I've seen this crossword clue in The Guardian
S
C
A
B
More clues leading to the result SCAB
- Small vehicle that one might pick?
- Unpopular worker provided with cards ultimately, then taxi
- Specifically muscle in to work when others are out
- Crusty despicable type?
- Payment method rejected, one working while others don't
- Ultimately, this taxi’s not one loved by unions
- Son needs taxi? He won’t come out
- He’s not out of US Cabinet
- Article penned by second-century bishop, one undermining union
- It covers physical damage caused by small carrier
Buddy explains!

The straight part
We know that "skin disease" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case skin disease = scab.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SCAB mean?
SCAB noun- An incrustation over a sore, wound, vesicle, or pustule, formed during healing.
- The scabies.
- The mange, especially when it appears on sheep.
- Any of several different diseases of potatoes producing pits and other damage on their surface, caused by streptomyces bacteria (but formerly believed to be caused by a fungus).
- Common scab, a relatively harmless variety of scab (potato disease) caused by Streptomyces scabies.
- Any one of various more or less destructive fungal diseases that attack cultivated plants, forming dark-colored crustlike spots.
- (founding) A slight irregular protuberance which defaces the surface of a casting, caused by the breaking away of a part of the mold.
- A mean, dirty, paltry fellow.
- A worker who acts against trade union policies, especially a strikebreaker.
- To become covered by a scab or scabs.
- To form into scabs and be shed, as damaged or diseased skin.
- To remove part of a surface (from).
- To act as a strikebreaker.
- To beg (for), to cadge or bum.