The most common and most likely answer to this crossword clue is the 6 letter word SATNAV
S
A
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N
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V
More clues leading to the result SATNAV
- GPS device oddly starts getting vehicle to reverse
- Guide rested by reversing vehicle
- Assistance for driver seated on overturned vehicle
- Guidance system sailors mostly used by day
- What’s positioned vehicle turning up?
- Driving aid positioned in front of reversing vehicle
- Day service detailed, guide on the way
- Director of a vast production incorporating any number
- Vehicle with endless job when reversing gets driving aid
- Camper director?
Buddy explains!

The straight part
We know that "Guiding system en route" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guiding system en route = satnav.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SATNAV mean?
SATNAV noun- A satellite navigation system.
- A satellite navigation system receiver.
- A civilian GPS receiver.