Cryptic crossword clue
Vasant designed Guiding system en route 6

The most common and most likely answer to this crossword clue is the 6 letter word SATNAV

S
A
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N
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V


Buddy explains!

The straight part
We know that "Guiding system en route" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guiding system en route = satnav.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SATNAV mean?

SATNAV noun
  1. A satellite navigation system.
  2. A satellite navigation system receiver.
  3. A civilian GPS receiver.

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