The most common and most likely answer to this crossword clue is the 6 letter word COSMOS
I've seen this crossword clue in The Daily Telegraph
C
O
S
M
O
S
More clues leading to the result COSMOS
- Doctors attending function — all-star affair?
- World of society in care of doctors
- World order mistakenly comes across as without cares?
- Universe composed of suns, made of stardust, primarily
- All out there, Greek doctors?
- Expressions of surprise about odd parts of some universe
- Plant in orderly system
- Everything ordered had highest price with regular 25 per cent reductions
- Report of Soviet satellite’s ordered system
- Every second, in echoes, a moon’s embodying creation
Buddy explains!

The straight part
We know that "Vast area" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case vast area = cosmos.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does COSMOS mean?
COSMOS noun- The universe.
- An ordered, harmonious whole.
- Any of various mostly Mexican herbs of the genus Cosmos having radiate heads of variously coloured flowers and pinnate leaves.
- A cosmopolitan, a cocktail containing vodka, triple sec, lime juice and cranberry juice.