Cryptic crossword clue
Vatican lost nun, incredibly fit fighter 14

The most common and most likely answer to this crossword clue is the 14 letter word ANTICONVULSANT

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Buddy explains!

The straight part
We know that "fit fighter" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fit fighter = anticonvulsant.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

ANTICONVULSANT noun
  1. An agent that prevents, stops, or lessens convulsions.
ANTICONVULSANT adjective
  1. (pharmaceutical effect) Acting as an anticonvulsant.

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