The most common and most likely answer to this crossword clue is the 6 letter word ROBUST
I've seen this crossword clue in The Guardian
R
O
B
U
S
T
More clues leading to the result ROBUST
- Strong, but run over and broken
- Healthy old boy going into decline
- Strong: alternatively, on reflection, broken
- Tough case of decay limiting public transport
- Direct section of Cairo bus trip
- Take our money? Time to be strong
- Firm or round boobs
- Vigorous, decline to take public transport
- Boisterous rubbish coach enters into
- Steal our belongings? Time to get tough!
Buddy explains!

The straight part
We know that "Tough" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tough = robust.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ROBUST mean?
ROBUST adjective- Evincing strength and health; strong.
- Violent; rough; rude.
- Requiring strength or vigor
- Sensible (of intellect etc.); straightforward, not given to or confused by uncertainty or subtlety
- Designed or evolved in such a way as to be resistant to total failure despite partial damage.
- Resistant or impervious to failure regardless of user input or unexpected conditions.
- Not greatly influenced by errors in assumptions about the distribution of sample errors.