The most common and most likely answer to this crossword clue is the 6 letter word MALICE
I've seen this crossword clue in The Times
M
A
L
I
C
E
More clues leading to the result MALICE
- Outrageous claim over English evil intent
- Venom shown by nation over evacuation of Chile
- Chap capturing official’s heart creates ill-will
- Michael is heartless, twisted and evil
- Evil intent from maiden, someone who had adventures?
- Commons staff guzzling large one for spite
- Liberal Independent enters club, causing ill-will
- Out of spite, start to malign girl
- Ill-will of many to a girl
- Venom in cobras initially collected by boy, say?
Buddy explains!

The straight part
We know that "Venom" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case venom = malice.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MALICE mean?
MALICE noun- Intention to harm or deprive in an illegal or immoral way. Desire to take pleasure in another's misfortune.
- An intention to do injury to another party, which in many jurisdictions is a distinguishing factor between the crimes of murder and manslaughter.
- To intend to cause harm; to bear malice.