Cryptic crossword clue
Very harmful to take out city on Atlantic coast, American 11

The most common and most likely answer to this crossword clue is the 11 letter word DELETERIOUS

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "Very harmful" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case very harmful = deleterious.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DELETERIOUS mean?

DELETERIOUS adjective
  1. Harmful often in a subtle or unexpected way.
  2. Having lower fitness.

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