Cryptic crossword clue
Very lively South American city, in our opinion 7

The most common and most likely answer to this crossword clue is the 7 letter word RIOTOUS

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "Very lively" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case very lively = riotous.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RIOTOUS mean?

RIOTOUS adjective
  1. Having the characteristics of a riot
  2. Causing, inciting or taking part in a riot
  3. Unrestrained and boisterous; degenerate or dissolute

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