The most common and most likely answer to this crossword clue is the 10 letter word OMNIPOTENT
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More clues leading to the result OMNIPOTENT
- Tempt with onion crackers, supremely strong
- Very powerful potion men concocted by end of experiment
- Supreme surgeon's work held back by ointment supply
- Almighty muddle in poem not finally relevant
- Supreme order to speed with energy through parts of bible?
- All-powerful men opt into corruption
- God’s ‘power in unbridled emotion’ [NT]
- Mention top criminal having total control
- All-powerful top men? Not one that’s sorted
- Very strong pimento not digested
Buddy explains!

The straight part
We know that "Very powerful" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case very powerful = omnipotent.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does OMNIPOTENT mean?
OMNIPOTENT noun- An omnipotent being.
- Having unlimited power, force or authority.
- Describing a cell (especially a stem cell) that is capable of developing into any type of cell or forming any type of tissue (also called a totipotent cell). See also pluripotent.