Cryptic crossword clue
Vigour and twitching in the digestive system 6

The most common and most likely answer to this crossword clue is the 6 letter word PEPTIC

P
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Buddy explains!

The straight part
We know that "in the digestive system" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in the digestive system = peptic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PEPTIC mean?

PEPTIC noun
  1. An agent that promotes digestion.
  2. (in the plural) The digestive organs.
PEPTIC adjective
  1. Of, pertaining to, capable of, or aiding digestion.
  2. Of or pertaining to pepsin.

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