The most common and most likely answer to this crossword clue is the 6 letter word PEPTIC
P
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More clues leading to the result PEPTIC
- Digestive spasm after fizz
- Spasm follows on from ginger digestive
- Concerned with digestion? Go getting nervous reaction
- Vigour and twitching in the digestive system
- Exercise pressure preceding spasm of digestion
- Spirit given sudden shake is good for digestion
- By the sound of it Jim’s in charge of having a good digestion
- … effervescence precedes spasm of the digestive system
- Go with complaint relating to digestion
- Exercises twice before unwrapping rich digestive
Buddy explains!

The straight part
We know that "in the digestive system" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in the digestive system = peptic.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PEPTIC mean?
PEPTIC noun- An agent that promotes digestion.
- (in the plural) The digestive organs.
- Of, pertaining to, capable of, or aiding digestion.
- Of or pertaining to pepsin.