Cryptic crossword clue
Villa, maybe one with central heating in the middle of Napoli 6

The most common and most likely answer to this crossword clue is the 6 letter word PANCHO

P
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H
O

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The straight part
We know that "Villa, maybe" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case villa, maybe = pancho.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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