Cryptic crossword clue
Viral infection when affecting fine fellow gets one down 3

The most common and most likely answer to this crossword clue is the 3 letter word FLU

F
L
U

Buddy explains!

The straight part
We know that "Viral infection" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case viral infection = flu.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FLU mean?

FLU noun
  1. Influenza.
  2. Stomach flu.

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