Cryptic crossword clue
Virginia’s tyrant having less power — it’ll raise blood pressure 11

The most common and most likely answer to this crossword clue is the 11 letter word VASOPRESSOR

I've seen this crossword clue in The Times
V
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Buddy explains!

The straight part
We know that "it’ll raise blood pressure" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it’ll raise blood pressure = vasopressor.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

VASOPRESSOR noun
  1. An agent that causes such constriction.
VASOPRESSOR adjective
  1. Of or relating to the constriction of blood vessels, which usually causes a rise in blood pressure.

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