Cryptic crossword clue
Vis-à-vis Ola, Tess largely makes interaction impossible 8

The most common and most likely answer to this crossword clue is the 8 letter word ISOLATES

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Buddy explains!

The straight part
We know that "makes interaction impossible" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case makes interaction impossible = isolates.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ISOLATES mean?

ISOLATES noun
  1. Something that has been isolated.
ISOLATES verb
  1. To set apart or cut off from others.
  2. To place in quarantine or isolation.
  3. To separate a substance in pure form from a mixture.
  4. To insulate, or make free of external influence.
  5. To separate a pure strain of bacteria etc. from a mixed culture.
  6. To insulate an electrical component from a source of electricity.

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