The most common and most likely answer to this crossword clue is the 3 plus 3 letter word SEE RED
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More clues leading to the result SEE RED
- Get angry as one of the top players, without hesitation
- Large amount of water studied, we hear, hit the roof?
- Forecaster getting editor to show anger
- Visionary leader on paper to become mad
- Notice adverse traffic light and lose temper
- Realise that you have to stop and get very cross
- Get angry about sight of traffic lights
- Position of bishop and cardinal making one become angry
- Get mad with one predicting Delaware setback
- Get the message about ending of aid, and lose one’s temper
Buddy explains!

The straight part
We know that "/ / / /fly off the handle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case / / / /fly off the handle = see red.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.