Cryptic crossword clue
Vitality unknown in Grantchester at first 4

The most common and most likely answer to this crossword clue is the 4 letter word ZING

I've seen this crossword clue in The Times
Z
I
N
G


Buddy explains!

The straight part
We know that "Vitality" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case vitality = zing.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ZING mean?

ZING noun
  1. A short high-pitched humming sound, such as that made by a bullet or vibrating string.
  2. A witty insult or derogatory remark.
  3. Zest or vitality.
  4. Pleasant or exciting flavour of food.
ZING verb
  1. To move very quickly, especially while making a high-pitched hum.
ZING interjection
  1. A high pitched humming sound.
  2. Used to acknowledge a witty comeback, a zinger.

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