The most common and most likely answer to this crossword clue is the 10 letter word HARD-WIRED
I've seen this crossword clue in The Guardian
H
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D
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W
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More clues leading to the result HARD-WIRED
Buddy explains!
The straight part
We know that "unable to be changed" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case unable to be changed = hard-wired.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HARD-WIRED mean?
HARD-WIRED verb- To connect components by means of permanent electrical wires.
- To implement a feature in hardware rather than in software so that it cannot easily be changed.
- (by extension) To make a pattern of behaviour automatic.
- Designed to perform a specific task.
- (electronic communications) Of devices, closely or tightly coupled.
- Having a fixed placement (on a screen format for example.)
- Not changeable.
- In humans and animals, describing genetically determined, instinctive behavior, as opposed to learned behavior.