The most common and most likely answer to this crossword clue is the 5 letter word WILCO
W
I
L
C
O
More clues leading to the result WILCO
- I’ll do that when I’m legally called on, initially
- I’ll do that which is largely counted on at the outset
- When originally I left company it indicated acquiescence
- Roger might be followed by this learner in Caribbean business
- Left in central London company, as agreed
- I’ll do it — I’ll follow Roger
- Warrant officer employs a mirrored command line interface to generate a reply on the radio
- What signifies compliance from wily cop crossing limits
- An agreement to follow Roger?
Buddy explains!

The straight part
We know that "a reply on the radio" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a reply on the radio = wilco.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does WILCO mean?
WILCO interjection- (radio communications) Used to indicate agreement and compliance.
- A species of South American tree, Anadenanthera colubrina.