The most common and most likely answer to this crossword clue is the 4 letter word SKAT
S
K
A
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More clues leading to the result SKAT
Buddy explains!

The straight part
We know that "game of cards" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case game of cards = skat.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SKAT mean?
SKAT noun- A trick-taking card game for three players, popular in Germany.
- A widow of two cards in the game of skat.