The most common and most likely answer to this crossword clue is the 4 plus 7 letter word HOMO SAPIENS
I've seen this crossword clue in The Guardian
H
O
M
O
S
A
P
I
E
N
S
More clues leading to the result HOMO SAPIENS
- We move home with passion
- Term implying wisdom that’s peculiarly man’s? I hope so
- Man’s posh moniker, used regularly in evolution?
- Man destroyed by poison – shame!
- Endangered species with misguided emphasis on saving ourselves, primarily?
- Man moans — hope is abandoned
- Placing emphasis on accepting love is being human
- Man treating me has poison
Buddy explains!
The straight part
We know that "We" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case we = homo sapiens.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.