Cryptic crossword clue
We must have these industrial city pilots wiping out Resistance 10

The most common and most likely answer to this crossword clue is the 10 letter word ESSENTIALS

E
S
S
E
N
T
I
A
L
S

Buddy explains!

The straight part
We know that "We must have these" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case we must have these = essentials.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ESSENTIALS mean?

ESSENTIALS noun
  1. A necessary ingredient.
  2. A fundamental ingredient.

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