The most common and most likely answer to this crossword clue is the 10 letter word DEBILITATE
D
E
B
I
L
I
T
A
T
E
More clues leading to the result DEBILITATE
- Undermine reason to keep current literature
- Make feeble argument about current books etc.
- Undermine one fired up during discussion
- Make weak Labour leader object after immigration initially enters argument
- Weaken one ignited during argument
- Make weak argument about Lilith going naked
- Weaken European power essentially in specified time
- Argument involving one intoxicated sap
Buddy explains!

The straight part
We know that "Weaken" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case weaken = debilitate.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DEBILITATE mean?
DEBILITATE verb- To make feeble; to weaken.