The most common and most likely answer to this crossword clue is the 10 letter word DO-GOODERY
I've seen this crossword clue in Financial Times
D
O
-
G
O
O
D
E
R
Y
Buddy explains!
The straight part
We know that "Well-meaning interference" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case well-meaning interference = do-goodery.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.