Cryptic crossword clue
West, almost neglectful, uses sweet talk 8

The most common and most likely answer to this crossword clue is the 8 letter word WHEEDLES

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "uses sweet talk" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case uses sweet talk = wheedles.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WHEEDLES mean?

WHEEDLES verb
  1. To cajole or attempt to persuade by flattery.
  2. To obtain by flattery, guile, or trickery.

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