The most common and most likely answer to this crossword clue is the 6 letter word APPALS
I've seen this crossword clue in The Daily Telegraph
A
P
P
A
L
S
Buddy explains!

The straight part
We know that "strikes with disgust" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case strikes with disgust = appals.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does APPALS mean?
APPALS verb- To fill with horror; to dismay.
- To make pale; to blanch.
- To weaken; to reduce in strength
- To grow faint; to become weak; to become dismayed or discouraged.
- To lose flavour or become stale.