The most common and most likely answer to this crossword clue is the 4 plus 2 plus 3 plus 6 letter word PICK UP THE THREAD
P
I
C
K
U
P
T
H
E
T
H
R
E
A
D
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.