Cryptic crossword clue
What a woman in R&D completely altered 8

The most common and most likely answer to this crossword clue is the 8 letter word REHASHED

R
E
H
A
S
H
E
D

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The straight part
We know that "completely altered" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case completely altered = rehashed.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REHASHED mean?

REHASHED verb
  1. To repeat with minor variation.
  2. To analyze a prior contentious or embarrassing event.
  3. To recompute the structure of a hash table, taking into account any newly added items.

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