Cryptic crossword clue
What could be uneasier than a nervous condition? 12

The most common and most likely answer to this crossword clue is the 12 letter word NEURASTHENIA

I've seen this crossword clue in Independent
N
E
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R
A
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H
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A

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The straight part
We know that "a nervous condition?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a nervous condition? = neurasthenia.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEURASTHENIA mean?

NEURASTHENIA noun
  1. An ill-defined medical condition characterized by lassitude, fatigue, headache, and irritability, associated chiefly with emotional disturbance.

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