Cryptic crossword clue
What could make me fret — sinning, transgressions 13

The most common and most likely answer to this crossword clue is the 13 letter word INFRINGEMENTS

I've seen this crossword clue in The Times
I
N
F
R
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E
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S

Buddy explains!

The straight part
We know that "transgressions" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case transgressions = infringements.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INFRINGEMENTS mean?

INFRINGEMENTS noun
  1. A violation or breach, as of a law.
  2. An encroachment on a right, a person, a territory, or a property.

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