Cryptic crossword clue
What could make you uneasier than debilitation? 12

The most common and most likely answer to this crossword clue is the 12 letter word NEURASTHENIA

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEURASTHENIA mean?

NEURASTHENIA noun
  1. An ill-defined medical condition characterized by lassitude, fatigue, headache, and irritability, associated chiefly with emotional disturbance.

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