The most common and most likely answer to this crossword clue is the 8 letter word APERIENT
I've seen this crossword clue in The Guardian
A
P
E
R
I
E
N
T
More clues leading to the result APERIENT
- Frenchman’s duck, caught by a favourite opener
- A cat or dog should eat nothing foreign as treatment for constipation
- What helps one go without head on beer? A pint, possibly
- Son of Welsh queen that’s initially nervous taking laxative
- Not a thing for Parisian to feed to Minou possibly!
- Drug that is seized by troubled parent
- Take off and tear round island — that should get you going
- Pain 19 treated with mild laxative
- Purgative “I repent”, a release
- Sort of medicine that gives a patient hesitation for a time
Buddy explains!

The straight part
We know that "What helps one go" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what helps one go = aperient.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does APERIENT mean?
APERIENT noun- A laxative, either in the form of a medicine or a food such as asparagus or hops, which has the effect of moving the bowels, or aiding digestion and preventing constipation.
- Having a gentle laxative effect.