Cryptic crossword clue
What in general comprises loathing 6

The most common and most likely answer to this crossword clue is the 6 letter word HATING

H
A
T
I
N
G

Buddy explains!

The straight part
We know that "loathing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loathing = hating.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HATING mean?

HATING verb
  1. To dislike intensely or greatly.
  2. To experience hatred.

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