The most common and most likely answer to this crossword clue is the 6 letter word SISTRA
S
I
S
T
R
A
Buddy explains!
The straight part
We know that "What makes an Isis rite – i.e. in these being rattled" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what makes an isis rite – i.e. in these being rattled = sistra.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SISTRA mean?
SISTRA noun- An ancient Egyptian musical instrument, to be shaken, consisting of a metal frame holding percussive metal beads.